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螺環
螺環 spiro： 脂環烴分子中兩個碳環共有一個碳原子稱為螺環烴，可形成螺環化合物。螺環結構與平面的芳香結構相比，有著更大的空間三維結構，而且結構更加新穎，從成藥性角度分析，化合物結構中含有太多平面的芳香環結構時成藥性下降，在藥物分子中引入螺環不僅更容易獲得專利保護，也有助于提升化合物穩定性，改善藥代動力學性質，因此，螺環在藥物設計中的應用已經逐漸引起藥物化學家的重視，目前已有很多上市藥物均含有螺環結構。
![1000933-99-2|(6-羥基螺[3.3]庚-2-基)氨基甲酸叔丁酯|tert-butyl N-{6-hydroxyspiro[3.3]heptan-2-yl}carbamate](https://images.chemany.com/attachments/products_new/svg/1000933-99-2.svg)
1000933-99-2
(6-羥基螺[3.3]庚-2-基)氨基甲酸叔丁酯
![1001907-64-7|5,8-二氧雜螺[3.4]辛烷-2-羧酸|5,8-dioxaspiro[3.4]octane-2-carboxylic acid](https://images.chemany.com/attachments/products_new/svg/1001907-64-7.svg)
1001907-64-7
5,8-二氧雜螺[3.4]辛烷-2-羧酸
![1003564-37-1|7-環丙基-2,7-二氮雜螺[3.5]壬烷|7-cyclopropyl-2,7-diazaspiro[3.5]nonane](https://images.chemany.com/attachments/products_new/svg/1003564-37-1.svg)
1003564-37-1
7-環丙基-2,7-二氮雜螺[3.5]壬烷
![100510-66-5|6'-氨基螺[環戊烷-1,3'-二氫吲哚]-2'-酮|6'-amino-1',2'-dihydrospiro[cyclopentane-1,3'-indol]-2'-one](https://images.chemany.com/attachments/products_new/svg/100510-66-5.svg)
100510-66-5
6'-氨基螺[環戊烷-1,3'-二氫吲哚]-2'-酮
![1005-85-2|2-氮雜螺[4.5]癸-1-酮|2-azaspiro[4.5]decan-1-one](https://images.chemany.com/attachments/products_new/svg/1005-85-2.svg)
1005-85-2
2-氮雜螺[4.5]癸-1-酮
![1007400-90-9|3-(環丙基甲基)-1-氧雜-3,8-二氮雜螺[4.5]癸-2-酮|3-(cyclopropylmethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one](https://images.chemany.com/attachments/products_new/svg/1007400-90-9.svg)
1007400-90-9
3-(環丙基甲基)-1-氧雜-3,8-二氮雜螺[4.5]癸-2-酮
![1010-26-0|1,1-環己基二乙酸酐|3-oxaspiro[5.5]undecane-2,4-dione](https://images.chemany.com/attachments/products_new/svg/1010-26-0.svg)
1010-26-0
1,1-環己基二乙酸酐
![1013033-83-4|1-氧代-3-苯基-2,7-二氮雜螺[3.5]壬烷-7-羧酸叔丁酯|tert-butyl 1-oxo-3-phenyl-2,7-diazaspiro[3.5]nonane-7-carboxylate](https://images.chemany.com/attachments/products_new/svg/1013033-83-4.svg)
1013033-83-4
1-氧代-3-苯基-2,7-二氮雜螺[3.5]壬烷-7-羧酸叔丁酯
![1017540-91-8|2-{3-氮雜螺[5.5]十一烷-9-基}乙酸甲酯鹽酸鹽|methyl 2-{3-azaspiro[5.5]undecan-9-yl}acetate hydrochloride](https://images.chemany.com/attachments/products_new/svg/1017540-91-8.svg)
1017540-91-8
2-{3-氮雜螺[5.5]十一烷-9-基}乙酸甲酯鹽酸鹽
![1018608-18-8|9-芐基-1-氧雜-4,9-二氮雜螺[5.5]十一烷|9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane](https://images.chemany.com/attachments/products_new/svg/1018608-18-8.svg)
1018608-18-8
9-芐基-1-氧雜-4,9-二氮雜螺[5.5]十一烷
![1019208-04-8|3-芐基-3-氮雜螺[雙環[3.2.1]辛烷-8,2'-[1,3]二氧戊環]|3-benzyl-3-azaspiro[bicyclo[3.2.1]octane-8,2'-[1,3]dioxolane]](https://images.chemany.com/attachments/products_new/svg/1019208-04-8.svg)
1019208-04-8
3-芐基-3-氮雜螺[雙環[3.2.1]辛烷-8,2'-[1,3]二氧戊環]
![1021117-39-4|[3-(4-氟芐基)-2,4-二氧代-1,3,8-三氮雜螺[4.5]癸-8-基]乙酸|2-{3-[(4-fluorophenyl)methyl]-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl}acetic acid](https://images.chemany.com/attachments/products_new/svg/1021117-39-4.svg)
1021117-39-4
[3-(4-氟芐基)-2,4-二氧代-1,3,8-三氮雜螺[4.5]癸-8-基]乙酸
![1021-25-6|1-苯基-1,3,8-三氮雜螺[4.5]癸-4-酮|1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one](https://images.chemany.com/attachments/products_new/svg/1021-25-6.svg)
1021-25-6
1-苯基-1,3,8-三氮雜螺[4.5]癸-4-酮
![1023301-84-9|2,7-二氮雜螺[3.5]壬烷-7-甲酸叔丁酯鹽酸鹽|tert-butyl 2,7-diazaspiro[3.5]nonane-7-carboxylate hydrochloride](https://images.chemany.com/attachments/products_new/svg/1023301-84-9.svg)
1023301-84-9
2,7-二氮雜螺[3.5]壬烷-7-甲酸叔丁酯鹽酸鹽
![1023301-88-3|2,9-二氮雜螺[5.5]十一烷-2-羧酸叔丁酯鹽酸鹽|tert-butyl 2,9-diazaspiro[5.5]undecane-2-carboxylate hydrochloride](https://images.chemany.com/attachments/products_new/svg/1023301-88-3.svg)
1023301-88-3
2,9-二氮雜螺[5.5]十一烷-2-羧酸叔丁酯鹽酸鹽
![1023595-11-0|1-氧代-4,9-二氮雜螺[5.5]十一烷-4-羧酸叔丁酯|tert-butyl 1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate](https://images.chemany.com/attachments/products_new/svg/1023595-11-0.svg)
1023595-11-0
1-氧代-4,9-二氮雜螺[5.5]十一烷-4-羧酸叔丁酯
![1023595-19-8|2,9-二氮雜螺[5.5]十一烷-9-羧酸叔丁酯|tert-butyl 2,9-diazaspiro[5.5]undecane-9-carboxylate](https://images.chemany.com/attachments/products_new/svg/1023595-19-8.svg)
1023595-19-8
2,9-二氮雜螺[5.5]十一烷-9-羧酸叔丁酯
![1023814-92-7|6-氧代螺[3.3]庚烷-2,2-二羧酸|6-oxospiro[3.3]heptane-2,2-dicarboxylic acid](https://images.chemany.com/attachments/products_new/svg/1023814-92-7.svg)
1023814-92-7
6-氧代螺[3.3]庚烷-2,2-二羧酸
![1025662-38-7|5-氟螺[二氫吲哚-3,4'-哌啶]-2-酮|5-fluoro-1,2-dihydrospiro[indole-3,4'-piperidin]-2-one](https://images.chemany.com/attachments/products_new/svg/1025662-38-7.svg)
1025662-38-7
5-氟螺[二氫吲哚-3,4'-哌啶]-2-酮
![1026796-16-6|2,5,7-三氮雜螺[3.4]辛烷-6,8-二酮|2,5,7-triazaspiro[3.4]octane-6,8-dione](https://images.chemany.com/attachments/products_new/svg/1026796-16-6.svg)
1026796-16-6
2,5,7-三氮雜螺[3.4]辛烷-6,8-二酮
![1026796-27-9|2,5,7-三氮雜螺[3.4]辛烷-6,8-二酮鹽酸鹽|2,5,7-triazaspiro[3.4]octane-6,8-dione hydrochloride](https://images.chemany.com/attachments/products_new/svg/1026796-27-9.svg)
1026796-27-9
2,5,7-三氮雜螺[3.4]辛烷-6,8-二酮鹽酸鹽
![1031927-14-6|1,9-二氮雜螺[5.5]十一烷-9-羧酸叔丁酯|tert-butyl 1,9-diazaspiro[5.5]undecane-9-carboxylate](https://images.chemany.com/attachments/products_new/svg/1031927-14-6.svg)
1031927-14-6
1,9-二氮雜螺[5.5]十一烷-9-羧酸叔丁酯
![1031928-36-5|8-芐基-1,8-二氮雜螺[4.5]癸-2-酮|8-benzyl-1,8-diazaspiro[4.5]decan-2-one](https://images.chemany.com/attachments/products_new/svg/1031928-36-5.svg)
1031928-36-5
8-芐基-1,8-二氮雜螺[4.5]癸-2-酮
![1032143-15-9|1-氧代-2,3-二氫-1H-螺[異喹啉-4,4'-哌啶]-1'-羧酸叔丁酯|tert-butyl 1-oxo-2,3-dihydro-1H-spiro[isoquinoline-4,4'-piperidine]-1'-carboxylate](https://images.chemany.com/attachments/products_new/svg/1032143-15-9.svg)
1032143-15-9
1-氧代-2,3-二氫-1H-螺[異喹啉-4,4'-哌啶]-1'-羧酸叔丁酯
