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連接子 Connexon： 連接子應(yīng)用于ADC和PROTAC，在PROTAC中，連接PROTAC兩部分（一個(gè)用于識(shí)別E3泛素連接酶的小肽殘基和一個(gè)可以被靶向蛋白識(shí)別的配體）的中間連接體。連接體的長度是隨機(jī)選擇的，長度從12個(gè)碳到20多個(gè)碳不等。一個(gè)最佳的連接體會(huì)使得兩個(gè)部分（目標(biāo)蛋白和E3連接酶）之間擁有最大程度的相互作用，從而導(dǎo)致目標(biāo)蛋白的高效泛素化和最終降解。 在ADC中，連接子通過化學(xué)鍵將抗體與毒素連接，幫助抗體選擇性地將細(xì)胞毒性藥物遞送到腫瘤細(xì)胞，并準(zhǔn)確地在腫瘤部位釋放細(xì)胞毒性藥物；連接子在ADC的制備和儲(chǔ)存以及體循環(huán)過程中，也發(fā)揮著重要作用。ADC中連接子分為可裂解和不可裂解兩大類。
1008402-79-6
雙取代丙烯酸琥珀酰亞胺酯-二十四聚乙二醇
![101187-39-7|1,11-二疊氮基-3,6,9-三氧雜十一烷|1-azido-2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethane](https://images.chemany.com/attachments/products_new/svg/101187-39-7.svg)
101187-39-7
1,11-二疊氮基-3,6,9-三氧雜十一烷
![112241-19-7|4-(1-(2-吡啶基二硫基)乙基)苯甲酸N-羥基琥珀亞酰胺酯|2,5-dioxopyrrolidin-1-yl 4-[1-(pyridin-2-yldisulfanyl)ethyl]benzoate](https://images.chemany.com/attachments/products_new/svg/112241-19-7.svg)
112241-19-7
4-(1-(2-吡啶基二硫基)乙基)苯甲酸N-羥基琥珀亞酰胺酯
![1137109-21-7|2,5-二氧代-1-吡咯烷基酯|2,5-dioxopyrrolidin-1-yl 1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12,15,18-hexaoxahenicosan-21-oate](https://images.chemany.com/attachments/products_new/svg/1137109-21-7.svg)
1137109-21-7
2,5-二氧代-1-吡咯烷基酯
1174157-65-3
炔丙基-N-羥基酯
1239017-80-1
2,5-二氧雜吡咯烷-1-基3-(3-甲基-3H-二氮雜-3-基)丙酸酯
![1236196-77-2|4-(4-(丙-2-炔-1-基氧基)苯甲酰基)苯甲酸|4-[4-(prop-2-yn-1-yloxy)benzoyl]benzoic acid](https://images.chemany.com/attachments/products_new/svg/1236196-77-2.svg)
1236196-77-2
4-(4-(丙-2-炔-1-基氧基)苯甲酰基)苯甲酸
![1334177-95-5|SPDP-PEG4-NHS ester|2,5-dioxopyrrolidin-1-yl 1-[3-(pyridin-2-yldisulfanyl)propanamido]-3,6,9,12-tetraoxapentadecan-15-oate](https://images.chemany.com/attachments/products_new/svg/1334177-95-5.svg)
1334177-95-5
SPDP-PEG4-NHS ester
![1353016-71-3|DBCO-NHS酯|2,5-dioxopyrrolidin-1-yl 4-{2-azatricyclo[10.4.0.0?,?]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-4-oxobutanoate](https://images.chemany.com/attachments/products_new/svg/1353016-71-3.svg)
1353016-71-3
DBCO-NHS酯
1393330-40-9
Propargyl-PEG5-NHS ester
![1395786-30-7|DBCO馬來酰亞胺|N-(3-{2-azatricyclo[10.4.0.0?,?]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl}-3-oxopropyl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide](https://images.chemany.com/attachments/products_new/svg/1395786-30-7.svg)
1395786-30-7
DBCO馬來酰亞胺
![158913-22-5|SPDP-C6-NHS ester|2,5-dioxopyrrolidin-1-yl 6-[3-(pyridin-2-yldisulfanyl)propanamido]hexanoate](https://images.chemany.com/attachments/products_new/svg/158913-22-5.svg)
158913-22-5
SPDP-C6-NHS ester
1609651-90-2
炔-PEG4-馬來酰亞胺
![1480516-75-3|DBCO-PEG4-馬來酰亞胺|N-(3-{2-azatricyclo[10.4.0.0?,?]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl}-3-oxopropyl)-1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12-tetraoxapentadecan-15-amide](https://images.chemany.com/attachments/products_new/svg/1480516-75-3.svg)
1480516-75-3
DBCO-PEG4-馬來酰亞胺
151038-94-7
6-(2,5-二氧代-2,5-二氫-1H-吡咯-1-基)己烷肼2,2,2-三氟乙酸酯
![1426827-79-3|(1R,8S,9s)-雙環(huán)[6.1.0]壬-4-炔-9-基甲基琥珀酰亞胺碳酸酯|[(1R,8S,9R)-bicyclo[6.1.0]non-4-yn-9-yl]methyl 2,5-dioxopyrrolidin-1-yl carbonate](https://images.chemany.com/attachments/products_new/svg/1426827-79-3.svg)
1426827-79-3
(1R,8S,9s)-雙環(huán)[6.1.0]壬-4-炔-9-基甲基琥珀酰亞胺碳酸酯
![1435934-53-4|二苯并環(huán)辛基雙硫鍵 N-羥基琥珀酰亞胺酯|2,5-dioxopyrrolidin-1-yl 3-{[2-(4-{2-azatricyclo[10.4.0.0?,?]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-4-oxobutanamido)ethyl]disulfanyl}propanoate](https://images.chemany.com/attachments/products_new/svg/1435934-53-4.svg)
1435934-53-4
二苯并環(huán)辛基雙硫鍵 N-羥基琥珀酰亞胺酯
![142702-31-6|1,1'-((3,3'-二硫(丙酰基))雙(氧基))雙(2,5-二氧代吡咯烷-3-磺酸)鈉鹽|2,5-dioxo-3-[(sodiooxy)sulfonyl]pyrrolidin-1-yl 3-{[3-({2,5-dioxo-3-[(sodiooxy)sulfonyl]pyrrolidin-1-yl}oxy)-3-oxopropyl]disulfanyl}propanoate](https://images.chemany.com/attachments/products_new/svg/142702-31-6.svg)
142702-31-6
1,1'-((3,3'-二硫(丙酰基))雙(氧基))雙(2,5-二氧代吡咯烷-3-磺酸)鈉鹽
![142702-32-7|Sulfo EGS|2,5-dioxo-3-[(sodiooxy)sulfonyl]pyrrolidin-1-yl 1-(2-{[4-({2,5-dioxo-3-[(sodiooxy)sulfonyl]pyrrolidin-1-yl}oxy)-4-oxobutanoyl]oxy}ethyl) butanedioate](https://images.chemany.com/attachments/products_new/svg/142702-32-7.svg)
142702-32-7
Sulfo EGS
1438415-89-4
TCO-PNB ester
![144650-93-1|Sulfo-SIAB (sodium)|2,5-dioxo-3-[(sodiooxy)sulfonyl]pyrrolidin-1-yl 4-(2-iodoacetamido)benzoate](https://images.chemany.com/attachments/products_new/svg/144650-93-1.svg)
144650-93-1
Sulfo-SIAB (sodium)
![1644644-96-1|Methyltetrazine-Ph-NHS ester|2,5-dioxopyrrolidin-1-yl 2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]acetate](https://images.chemany.com/attachments/products_new/svg/1644644-96-1.svg)
1644644-96-1
Methyltetrazine-Ph-NHS ester
![169751-10-4|Sulfo-SPDP-C6-NHS (sodium)|2,5-dioxo-3-[(sodiooxy)sulfonyl]pyrrolidin-1-yl 6-[3-(pyridin-2-yldisulfanyl)propanamido]hexanoate](https://images.chemany.com/attachments/products_new/svg/169751-10-4.svg)
169751-10-4
Sulfo-SPDP-C6-NHS (sodium)
![2101722-60-3|Mal-amido-PEG12-NHS ester|2,5-dioxopyrrolidin-1-yl 1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxanonatriacontan-39-oate](https://images.chemany.com/attachments/products_new/svg/2101722-60-3.svg)
2101722-60-3
Mal-amido-PEG12-NHS ester
