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脂肪酸修飾側鏈
脂肪酸修飾側鏈是一種小分子修飾物，是改變胰島素類產品藥代動力學行為的重要因素之一。多肽類藥物在臨床上存在半衰期較短易被降解的問題，在多肽類藥物中引入脂肪酸修飾側鏈，可以增加藥物的疏水性，提高生物半衰期，從而降低用藥劑量、減少用藥頻率。 在脂肪酸修飾藥物的開發中，可根據脂肪酸修飾側鏈的結構特征及制備工藝，充分評估其質量對產品安全性、有效性和質量可控性的潛在影響，需要重點關注脂肪酸修飾側鏈相關雜質的監測與控制，包括工藝相關有機物、修飾異構體、降解物雜質、遺傳毒性雜質和元素雜質等。
![1118767-15-9|tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu|tert-butyl 17-{[(2S)-1-(tert-butoxy)-4-({2-[2-({[2-(2-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethoxy}ethoxy)ethyl]carbamoyl}methoxy)ethoxy]ethyl}carbamoyl)-1-oxobutan-2-yl]carbamoyl}heptadecanoate](https://images.chemany.com/attachments/products_new/svg/1118767-15-9.svg)
1118767-15-9
tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu
![1188328-37-1|tBuO-Ara-Glu(AEEA-AEEA-OH)-OtBu|2-(2-{2-[2-(2-{2-[(4S)-5-(tert-butoxy)-4-[20-(tert-butoxy)-20-oxoicosanamido]-5-oxopentanamido]ethoxy}ethoxy)acetamido]ethoxy}ethoxy)acetic acid](https://images.chemany.com/attachments/products_new/svg/1188328-37-1.svg)
1188328-37-1
tBuO-Ara-Glu(AEEA-AEEA-OH)-OtBu
![2460751-66-8|Fmoc-L-Lys[C20-OtBu-Glu(OtBu)-AEEA-AEEA]-OH|(2S)-6-[2-(2-{2-[2-(2-{2-[(4R)-5-(tert-butoxy)-4-[20-(tert-butoxy)-20-oxoicosanamido]-5-oxopentanamido]ethoxy}ethoxy)acetamido]ethoxy}ethoxy)acetamido]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid](https://images.chemany.com/attachments/products_new/svg/2460751-66-8.svg)
2460751-66-8
Fmoc-L-Lys[C20-OtBu-Glu(OtBu)-AEEA-AEEA]-OH
![294855-91-7|Pal-Glu(OSu)-OH|(2S)-5-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-hexadecanamido-5-oxopentanoic acid](https://images.chemany.com/attachments/products_new/svg/294855-91-7.svg)
294855-91-7
Pal-Glu(OSu)-OH
536721-25-2
Palm-Glu-OtBu
![843666-26-2|C16-(OtBu)-Glu(OSU)-OtBu|1-tert-butyl 2,5-dioxopyrrolidin-1-yl (2S)-2-[16-(tert-butoxy)-16-oxohexadecanamido]pentanedioate](https://images.chemany.com/attachments/products_new/svg/843666-26-2.svg)
843666-26-2
C16-(OtBu)-Glu(OSU)-OtBu
![943586-12-7|HO-C16-Glu(OSU)-OH|15-{[(1S)-1-carboxy-4-[(2,5-dioxopyrrolidin-1-yl)oxy]-4-oxobutyl]carbamoyl}pentadecanoic acid](https://images.chemany.com/attachments/products_new/svg/943586-12-7.svg)
943586-12-7
HO-C16-Glu(OSU)-OH
